REGENERATIVE MEDICINE | Research and Science

KNEE REGENERATIVE MEDICINE | Research and Science

Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies.

Authored By:Law L, Qu W, et al.Spine Center; Mayo Clinic, Rochester, Minnesota, USA.

Published:Pain Med. 2018 Dec 29.

Open The Study

What this means: In this systematic review of stem cell therapy for orthopedic issues, almost 1000 patients were treated with no significant adverse events with treatment. Support in the literature is strongest for the use of bone marrow aspirate concentrate (BMAC) injections for the treatment of knee pain, but also showed improved symptoms for those with hip, tendon and spinal disc pain.

The Conservative Treatment of Osteoarthritis of the Knee.

Authored By:Bert JM, Endres NK, Tucker CJ, Davey AP.

Published:Orthopedics. 2018 Sep 1;41(5):256-260. doi: 10.3928/01477447-20180828-08

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What this means: Osteoarthritis has one of the highest associations for all-cause mortality, and decreased quality of life, in the United States. With advancements in Orthobiologic treatments, such as stem cell therapy, they should be considered as potential “step therapies” for patients wanting to delay joint replacement surgery.

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

Authored By:Hassan F1, Trebinjac S2, Murrell WD3,4, Maffulli N

Published:Br Med Bull. 2017 Jun 1;122(1):91-108

Open The Study

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

Intraarticular injection autologous platelet-rich plasma and bone marrow concentrate in a goat osteoarthritis model.

Authored By:Wang Z, Zhai C, Fei H, Hu J, Cui W, Wang Z, Li Z, Fan W.

Published:J Orthop Res. 2018 Feb 21.

Open The Study

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

SPINE REGENERATIVE MEDICINE | Research and Science

Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.

Authored By:Ishiguro H, Kaito T, Yarimitsu S, et al.

Published:Acta Biomater. 2019 Jan 25. pii: S1742-7061(19)30072-8.

Open The Study

What this means: Stem cell technology may soon be able to regenerate or even replace degenerative discs in the spine.

HIP REGENERATIVE MEDICINE | Research and Science

Pure bone marrow aspirate injection for chronic greater trochanteric pain syndrome: a case report.

Authored By:Henderson RG, Colberg RE.

Published:Andrews Sports Medicine & Orthopedic Center, Birmingham, AL – Pain Manag. 2018 Jul 1;8(4):271-275

Open The Study

What this means: Corticosteroid injections often fail to achieve long-term success in patients with lateral hip pain syndromes. Bone marrow stem cell therapy was an effective treatment for lateral hip pain from greater trochanteric pain syndrome (sometimes misdiagnosed as “hip bursitis”).

Greater Trochanteric Pain Syndrome: Percutaneous Tendon Fenestration Versus Platelet-Rich Plasma Injection for Treatment of Gluteal Tendinosis.

Authored By:Jacobson JA1, Yablon CM2, Henning PT3, Kazmers IS 4, Urquhart A5, Hallstrom B5, Bedi A5, Parameswaran A6.

Published:Journal of Ultrasound Medicine. 2016 Nov

Open The Study

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

FOOT/ANKLE REGENERATIVE MEDICINE | Research and Science

Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study.

Authored By:Boesen AP, Hansen R, Boesen MI, Malliaras P, Langberg H.

Published:Am J Sports Med. 2017 Jul

Open The Study

What this means: Achilles tendon injuries are difficult to treat. Treatment with PRP (platelet rich plasma) in combination with eccentric training (physical therapy) in chronic achilles tendon injuries seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone.

Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis.

Authored By:Fukawa T1, Yamaguchi S1, Akatsu Y1, Yamamoto Y1, Akagi R1, Sasho T1.

Published:Foot Ankle Int. 2017 Jun;38(6):596-604

Open The Study

What this means: Intra-articular injections of PRP resulted in no serious adverse effects and significantly reduced pain in the patients with ankle osteoarthritis( OA). Platelet Rich Plasma (PRP) treatment is a safe and effective option in the treatment of ankle OA.

A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy.

Authored By:Singh P, Madanipour S, Bhamra JS, Gill I

Published:Int Orthop. 2017 Apr 10

Open The Study

What this means: In the treatment of plantar fasciitis, Platelet rich plasma (PRP) injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections.

OSTEOARTHRITIS | Research and Science

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

Authored By:Hassan F1, Trebinjac S2, Murrell WD3,4, Maffulli N

Published:Br Med Bull. 2017 Jun 1;122(1):91-108

Open The Study

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

Intraarticular injection autologous platelet-rich plasma and bone marrow concentrate in a goat osteoarthritis model.

Authored By:Wang Z, Zhai C, Fei H, Hu J, Cui W, Wang Z, Li Z, Fan W.

Published:J Orthop Res. 2018 Feb 21.

Open The Study

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

TENDON INJURIES | Research and Science

Greater Trochanteric Pain Syndrome: Percutaneous Tendon Fenestration Versus Platelet-Rich Plasma Injection for Treatment of Gluteal Tendinosis.

Authored By:Jacobson JA1, Yablon CM2, Henning PT3, Kazmers IS 4, Urquhart A5, Hallstrom B5, Bedi A5, Parameswaran A6.

Published:Journal of Ultrasound Medicine. 2016 Nov

Open The Study

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study.

Authored By:Boesen AP, Hansen R, Boesen MI, Malliaras P, Langberg H.

Published:Am J Sports Med. 2017 Jul

Open The Study

What this means: Achilles tendon injuries are difficult to treat. Treatment with PRP (platelet rich plasma) in combination with eccentric training (physical therapy) in chronic achilles tendon injuries seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone.

ADVANCEMENTS IN STEM CELL THERAPY | Research and Science

Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies.

Authored By: Block TJ, Marinkovic M, Tran ON, Gonzalez AO, Marshall A, Dean DD, Chen XD.

Published: Stem Cell Res Ther. 2017 Oct 27;8(1):239.

Open The Study

What this means: Contrary to what companies are marketing regarding umbilical cord derived stem cells (or growth factor products) being superior in the elderly population, these results suggest that it is feasible to obtain large numbers of high-quality autologous MSCs from the elderly population. Further, it would be highly beneficial for the aging patient to establish personal stem cell banks that will allow serial infusions of “rejuvenated” MSCs for treating age-related diseases.

Musculoskeletal Injuries and Regenerative Medicine in the Elderly Patient.

Authored By: Cianca JC,  Jayaram P.

Published: Phys Med Rehabil Clin N Am. 2017 Nov;28(4):777-794. doi: 10.1016/j.pmr.2017.06.010.

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What this means: Over the past decade or more in the U.S., Regenerative Orthopedic procedures including stem cell therapy, platelet rich plasma (PRP), and prolotherapy have been effectively used as non-surgical interventions to treat orthopedic problems in an aging population.

 

Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies.

Authored By:Law L, Qu W, et al.Spine Center; Mayo Clinic, Rochester, Minnesota, USA.

Published:Pain Med. 2018 Dec 29.

Open The Study

What this means: In this systematic review of stem cell therapy for orthopedic issues, almost 1000 patients were treated with no significant adverse events with treatment. Support in the literature is strongest for the use of bone marrow aspirate concentrate (BMAC) injections for the treatment of knee pain, but also showed improved symptoms for those with hip, tendon and spinal disc pain.

Intraarticular injection autologous platelet-rich plasma and bone marrow concentrate in a goat osteoarthritis model.

Authored By:Wang Z, Zhai C, Fei H, Hu J, Cui W, Wang Z, Li Z, Fan W.

Published:J Orthop Res. 2018 Feb 21.

Open The Study

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.

Authored By:Ishiguro H, Kaito T, Yarimitsu S, et al.

Published:Acta Biomater. 2019 Jan 25. pii: S1742-7061(19)30072-8.

Open The Study

What this means: Stem cell technology may soon be able to regenerate or even replace degenerative discs in the spine.

Pure bone marrow aspirate injection for chronic greater trochanteric pain syndrome: a case report.

Authored By:Henderson RG, Colberg RE.

Published:Andrews Sports Medicine & Orthopedic Center, Birmingham, AL – Pain Manag. 2018 Jul 1;8(4):271-275

Open The Study

What this means: Corticosteroid injections often fail to achieve long-term success in patients with lateral hip pain syndromes. Bone marrow stem cell therapy was an effective treatment for lateral hip pain from greater trochanteric pain syndrome (sometimes misdiagnosed as “hip bursitis”).

PLATELET-RICH PLASMA THERAPY | Research and Science

Intraarticular injection autologous platelet-rich plasma and bone marrow concentrate in a goat osteoarthritis model.

Authored By:Wang Z, Zhai C, Fei H, Hu J, Cui W, Wang Z, Li Z, Fan W.

Published:J Orthop Res. 2018 Feb 21.

Open The Study

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

Greater Trochanteric Pain Syndrome: Percutaneous Tendon Fenestration Versus Platelet-Rich Plasma Injection for Treatment of Gluteal Tendinosis.

Authored By:Jacobson JA1, Yablon CM2, Henning PT3, Kazmers IS 4, Urquhart A5, Hallstrom B5, Bedi A5, Parameswaran A6.

Published:Journal of Ultrasound Medicine. 2016 Nov

Open The Study

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study.

Authored By:Boesen AP, Hansen R, Boesen MI, Malliaras P, Langberg H.

Published:Am J Sports Med. 2017 Jul

Open The Study

What this means: Achilles tendon injuries are difficult to treat. Treatment with PRP (platelet rich plasma) in combination with eccentric training (physical therapy) in chronic achilles tendon injuries seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone.

Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis.

Authored By:Fukawa T1, Yamaguchi S1, Akatsu Y1, Yamamoto Y1, Akagi R1, Sasho T1.

Published:Foot Ankle Int. 2017 Jun;38(6):596-604

Open The Study

What this means: Intra-articular injections of PRP resulted in no serious adverse effects and significantly reduced pain in the patients with ankle osteoarthritis( OA). Platelet Rich Plasma (PRP) treatment is a safe and effective option in the treatment of ankle OA.

A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy.

Authored By:Singh P, Madanipour S, Bhamra JS, Gill I

Published:Int Orthop. 2017 Apr 10

Open The Study

What this means: In the treatment of plantar fasciitis, Platelet rich plasma (PRP) injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections.

PROLOTHERAPY | Research and Science

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

Authored By:Hassan F1, Trebinjac S2, Murrell WD3,4, Maffulli N

Published:Br Med Bull. 2017 Jun 1;122(1):91-108

Open The Study

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

REGENERATIVE MEDICINE | Testimonials and Success Stories

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F. 520.306.4843
contact@rejuvmedicalsw.com

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Oro Valley, AZ 85704

Rejuv Medical Southwest is located in Southwest Arizona and provides clinical services to the surrounding cities: Tucson, Oro Valley, Catalina, Saddlebrooke, Oracle, Marana, Casa Grande, Green Valley, Nogales, Vail, Sahuarita, Phoenix, Gilbert, Chandler, Mesa, Tempe, Scottsdale, Glendale.

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